▶ GP88/PGRN is also known as:
▶ • GP88
▶ • Progranulin (PGRN)
▶ • PC cell-derived growth factor
▶ • (PCDGF)
▶ • PCDGF-GP88
▶ • Epithelin precursor
▶ • Acrogranin
▶ • Granulin-epithelin precursor (GEP)
▶ • Proepithelin (PEPI)
▶ • GP88
▶ • Progranulin (PGRN)
▶ • PC cell-derived growth factor
▶ • (PCDGF)
▶ • PCDGF-GP88
▶ • Epithelin precursor
▶ • Acrogranin
▶ • Granulin-epithelin precursor (GEP)
▶ • Proepithelin (PEPI)
Publications (chronological order)
Following are peer-reviewed journal publications that were authored
or co-authored by A&G Pharmaceutical scientists:
Zhou J, Gao G, Crabb JW, Serrero G. Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line. J Biol Chem. 1993 May 25;268(15):10863-9. PubMed PMID: 8496151.
Xia X, Serrero G. Identification of cell surface binding sites for PC-cell-derived growth factor, PCDGF, (epithelin/granulin precursor) on epithelial cells and fibroblasts. Biochem Biophys Res Commun. 1998 Apr 17;245(2):539-43. PubMed PMID: 9571191.
Zhang H, Serrero G. Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor). Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14202-7. PubMed PMID: 9826678; PubMed Central PMCID: PMC24351.
Lu R, Serrero G. Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. Biochem Biophys Res Commun. 1999 Mar 5;256(1):204-7. PubMed PMID: 10066447.
Lu R, Serrero G. Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3993-8. PubMed PMID: 10760271; PubMed Central PMCID: PMC18130.
Lu R, Serrero G. Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor). Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):142-7. PubMed PMID: 11134521; PubMed Central PMCID: PMC14558.
Serrero G, Lu R. Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells. Antioxid Redox Signal. 2001 Dec;3(6):969-79. PubMed PMID: 11813992.
Jones MB, Michener CM, Blanchette JO, Kuznetsov VA, Raffeld M, Serrero G, Emmert-Buck MR, Petricoin EF, Krizman DB, Liotta LA, Kohn EC. The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer. Clin Cancer Res. 2003 Jan;9(1):44-51. PubMed PMID: 12538450.
Wang W, Hayashi J, Kim WE, Serrero G. PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma. Clin Cancer Res. 2003 Jun;9(6):2221-8. PubMed PMID: 12796389.
Serrero G. Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis. Biochem Biophys Res Commun. 2003 Aug 29;308(3):409-13. Review. PubMed PMID: 12914763.
Serrero G, Ioffe OB. Expression of PC-cell-derived growth factor in benign and malignant human breast epithelium. Hum Pathol. 2003 Nov;34(11):1148-54. PubMed PMID: 14652816.
Pan CX, Kinch MS, Kiener PA, Langermann S, Serrero G, Sun L, Corvera J, Sweeney CJ, Li L, Zhang S, Baldridge LA, Jones TD, Koch MO, Ulbright TM, Eble JN, Cheng L. PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma. Clin Cancer Res. 2004 Feb 15;10(4):1333-7. PubMed PMID: 14977833.
Tangkeangsirisin W, Hayashi J, Serrero G. PC cell-derived growth factor mediates tamoxifen resistance and promotes tumor growth of human breast cancer cells. Cancer Res. 2004 Mar 1;64(5):1737-43. PubMed PMID: 14996734.
Tangkeangsirisin W, Serrero G. PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells. Carcinogenesis. 2004 Sep;25(9):1587-92. Epub 2004 Apr 29. PubMed PMID: 15117809.
Wang W, Hayashi J, Serrero G. PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma. Clin Cancer Res. 2006 Jan 1;12(1):49-56. PubMed PMID: 16397023.
Kim WE, Serrero G. PC cell-derived growth factor stimulates proliferation and confers Trastuzumab resistance to Her-2-overexpressing breast cancer cells. Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4192-9. PubMed PMID: 16857791.
Monami G, Emiliozzi V, Bitto A, Lovat F, Xu SQ, Goldoni S, Fassan M, Serrero G, Gomella LG, Baffa R, Iozzo RV, Morrione A. Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth. Am J Pathol. 2009 Mar;174(3):1037-47. Epub 2009 Jan 29. PubMed PMID: 19179604; PubMed Central PMCID: PMC2665763.
Lovat F, Bitto A, Xu SQ, Fassan M, Goldoni S, Metalli D, Wubah V, McCue P, Serrero G, Gomella LG, Baffa R, Iozzo RV, Morrione A. Proepithelin is an autocrine growth factor for bladder cancer. Carcinogenesis. 2009 May;30(5):861-8. Epub 2009 Feb 23. PubMed PMID: 19237611; PubMed Central PMCID: PMC2675649.
Following are peer-reviewed journal publications that were authored
or co-authored by A&G Pharmaceutical scientists:
Zhou J, Gao G, Crabb JW, Serrero G. Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line. J Biol Chem. 1993 May 25;268(15):10863-9. PubMed PMID: 8496151.
Xia X, Serrero G. Identification of cell surface binding sites for PC-cell-derived growth factor, PCDGF, (epithelin/granulin precursor) on epithelial cells and fibroblasts. Biochem Biophys Res Commun. 1998 Apr 17;245(2):539-43. PubMed PMID: 9571191.
Zhang H, Serrero G. Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor). Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14202-7. PubMed PMID: 9826678; PubMed Central PMCID: PMC24351.
Lu R, Serrero G. Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. Biochem Biophys Res Commun. 1999 Mar 5;256(1):204-7. PubMed PMID: 10066447.
Lu R, Serrero G. Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3993-8. PubMed PMID: 10760271; PubMed Central PMCID: PMC18130.
Lu R, Serrero G. Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor). Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):142-7. PubMed PMID: 11134521; PubMed Central PMCID: PMC14558.
Serrero G, Lu R. Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells. Antioxid Redox Signal. 2001 Dec;3(6):969-79. PubMed PMID: 11813992.
Jones MB, Michener CM, Blanchette JO, Kuznetsov VA, Raffeld M, Serrero G, Emmert-Buck MR, Petricoin EF, Krizman DB, Liotta LA, Kohn EC. The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer. Clin Cancer Res. 2003 Jan;9(1):44-51. PubMed PMID: 12538450.
Wang W, Hayashi J, Kim WE, Serrero G. PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma. Clin Cancer Res. 2003 Jun;9(6):2221-8. PubMed PMID: 12796389.
Serrero G. Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis. Biochem Biophys Res Commun. 2003 Aug 29;308(3):409-13. Review. PubMed PMID: 12914763.
Serrero G, Ioffe OB. Expression of PC-cell-derived growth factor in benign and malignant human breast epithelium. Hum Pathol. 2003 Nov;34(11):1148-54. PubMed PMID: 14652816.
Pan CX, Kinch MS, Kiener PA, Langermann S, Serrero G, Sun L, Corvera J, Sweeney CJ, Li L, Zhang S, Baldridge LA, Jones TD, Koch MO, Ulbright TM, Eble JN, Cheng L. PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma. Clin Cancer Res. 2004 Feb 15;10(4):1333-7. PubMed PMID: 14977833.
Tangkeangsirisin W, Hayashi J, Serrero G. PC cell-derived growth factor mediates tamoxifen resistance and promotes tumor growth of human breast cancer cells. Cancer Res. 2004 Mar 1;64(5):1737-43. PubMed PMID: 14996734.
Tangkeangsirisin W, Serrero G. PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells. Carcinogenesis. 2004 Sep;25(9):1587-92. Epub 2004 Apr 29. PubMed PMID: 15117809.
Wang W, Hayashi J, Serrero G. PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma. Clin Cancer Res. 2006 Jan 1;12(1):49-56. PubMed PMID: 16397023.
Kim WE, Serrero G. PC cell-derived growth factor stimulates proliferation and confers Trastuzumab resistance to Her-2-overexpressing breast cancer cells. Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4192-9. PubMed PMID: 16857791.
Monami G, Emiliozzi V, Bitto A, Lovat F, Xu SQ, Goldoni S, Fassan M, Serrero G, Gomella LG, Baffa R, Iozzo RV, Morrione A. Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth. Am J Pathol. 2009 Mar;174(3):1037-47. Epub 2009 Jan 29. PubMed PMID: 19179604; PubMed Central PMCID: PMC2665763.
Lovat F, Bitto A, Xu SQ, Fassan M, Goldoni S, Metalli D, Wubah V, McCue P, Serrero G, Gomella LG, Baffa R, Iozzo RV, Morrione A. Proepithelin is an autocrine growth factor for bladder cancer. Carcinogenesis. 2009 May;30(5):861-8. Epub 2009 Feb 23. PubMed PMID: 19237611; PubMed Central PMCID: PMC2675649.
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